PTPN13 Antibody

ArtNr	PRS-14-741-50uL
Hersteller	ProSci
Menge	50 uL
Quantity options	100 uL
Kategorie	Oncology Metabolism Cholesterol & Lipid Metabolism Antibodies By Cell Type Carcinoma Immunohistochemistry Western Blot Immunofluorescence Enzymes Fatty Acid Synthesis Primary Antibodies By Organ Brain Cancer
Typ	Antibody Primary
Format	Liquid
Applikationen	WB, IF, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
NCBI	PTPN13
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	PTPN13, FAP-1, HPTP1E, HPTPE1, Fas associated phosphatase 1, Phosphatase rip, PTP-BAS, PTP-E1, PTP-BL, PTP1E, PTPLE, PNP1, PTPL1
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Manufacturer - Applications	WB: 1:500 - 1:2000 IHC: 1:50 - 1:100 IF: 1:50 - 1:100
Shipping Temperature	blue ice or room temperature
Storage Conditions	Store at -20°C. Avoid freeze / thaw cycles.
Molecular Weight	Observed: 310kDa
Manufacturer - Research Area	Cancer, Cell Cycle, Immunology, Signal Transduction
Background	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.
Purification	Affinity purification
Buffer	PBS with 0.02% sodium azide, 50% glycerol, pH 7.3
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 250-500 of human PTPN13 (NP_542416.1).
Clonality	Polyclonal
NCBI Official Name	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
NCBI Organism	Homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

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Menge: 50 uL

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