IL12RB1 Antibody

IHC: 1:50 - 1:200

IF: 1:50 - 1:200

Store at -20°C. Avoid freeze / thaw cycles.

The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.

PBS with 0.02% sodium azide, 50% glycerol, pH 7.3

Polyclonal

Homo sapiens