PAK6 Antibody

Blue Ice

Predicted: 75 kDa
Observed: 70 kDa

PAK6 Antibody: The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK6 was initially identified as an androgen receptor in a yeast two hybrid screen and was found to be highly expressed in testis and prostate tissues. Later experiments have shown it to be activated by MAP kinase kinase 6 and p38 MAP kinase, suggesting that PAK6 may play a role in the cellular response to stress-related signals.

Trial Size

9910476

PRS-1207-0.1mg

1 mg/mL

PAK6 antibody can be used for the detection of PAK6 by Western blot at 1 - 4 μ g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ g/mL. For immunofluorescence start at 10 μ g/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

PAK6 antibody was raised against a 13 amino acid synthetic peptide from near the center of human PAK6.

The immunogen is located within amino acids 260 - 310 of PAK6.

p21 protein (Cdc42/Rac)-activated kinase 6

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.