PHAP I Antibody

Blue Ice

Predicted: 29kD
Observed: 29 kD

PHAP I Antibody: Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.

Trial Size, IAV

730318

PRS-1207-0.1mg

PRS-1476-0.1mg

1 mg/mL

WB: 1 μ g/mL; IHC: 2 μ g/mL; IF: 20 μ g/mL.
Antibody validated: Western Blot in human, mouse and rat samples; Immunohistochemistry in mouse samples; Immunofluorescence in mouse samples. All other applications and species not yet tested.

This polyclonal antibody has no cross-reaction to PHAP I2a and PHAP III.

Polyclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher.