IL-23 Antibody

Blue Ice

Predicted: 21kD
Observed: 22 kD

IL-23 Antibody: Like interleukin-27 (IL-27), IL-23 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the IL-12p40 subunit and a novel p19 subunit. IL-23 is secreted by activated dendritic cells, macrophages, and monocytes. Its biological activities include enhancing the proliferation of memory T cells and the production of IFN-gamma, IL-12, and TNF-α from activated T cells, and can stimulate macrophages to produce TNF-α and nitric oxide. It has also been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer.

Trial Size

42542809

Human IL-23 has one isoform (189aa, 20.7kD). Mouse IL-23 has one isoform (196aa, 22.1kD) and Rat IL-23 also has one isoform (196aa, 22kD). 3795 can detect human and mouse, and possibly detect rat.

PRS-1414-0.1mg

IL-23 Antibody is supplied in PBS containing 0.02% sodium azide.

Predicted species reactivity based on immunogen sequence: Horse: (94%), Pig: (82%), Rat: (76%), Guinea pig: (76%)

Polyclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher.