GNE Antibody

For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50

blue ice or room temperature

79 kDa

The protein encoded by this gene is a bifunctional enzymethat initiates and regulates the biosynthesis of N-acetylneuraminicacid (NeuAc), a precursor of sialic acids. It is a rate-limitingenzyme in the sialic acid biosynthetic pathway. Sialic acidmodification of cell surface molecules is crucial for theirfunction in many biologic processes, including cell adhesion andsignal transduction. Differential sialylation of cell surfacemolecules is also implicated in the tumorigenicity and metastaticbehavior of malignant cells. Mutations in this gene are associatedwith sialuria, autosomal recessive inclusion body myopathy, andNonaka myopathy. Alternative splicing of this gene results intranscript variants encoding different isoforms. [provided byRefSeq].

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This GNE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 169-197 amino acids from the N-terminal region of human GNE.

Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.