PDE6A Antibody

For WB starting dilution is: 1:1000

blue ice or room temperature

100 kDa

This gene encodes the cyclic-GMP (cGMP)-specificphosphodiesterase 6A alpha subunit, expressed in cells of theretinal rod outer segment. The phosphodiesterase 6 holoenzyme is aheterotrimer composed of an alpha, beta, and two gamma subunits.cGMP is an important regulator of rod cell membrane current, andits dynamic concentration is established by phosphodiesterase 6AcGMP hydrolysis and guanylate cyclase cGMP synthesis. The proteinis a subunit of a key phototransduction enzyme and participates inprocesses of transmission and amplification of the visual signal.Mutations in this gene have been identified as one cause ofautosomal recessive retinitis pigmentosa.

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This PDE6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the Central region of human PDE6A.

Rod cGMP-specific 3', 5'-cyclic phosphodiesterase subunit alpha

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.