NFKBIB Antibody

Primary Antibodies

Blue Ice

38 kDa

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL
(MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the
NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins
(NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by
trapping it in the cytoplasm. Phosphorylation of serine residues on
the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM
603258) marks them for destruction via the ubiquitination pathway,
thereby allowing activation of the NF-kappa-B complex. Activated
NFKB complex translocates into the nucleus and binds DNA at
kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or
5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G
purine; and Y is a C or T pyrimidine).

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This NFKBIB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 326-355 amino acids from the C-terminal region of human NFKBIB.

NF-kappa-B inhibitor beta

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.