NFKBIB Antibody

For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50

blue ice or room temperature

38 kDa

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL(MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form theNFKB complex. The NFKB complex is inhibited by I-kappa-B proteins(NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B bytrapping it in the cytoplasm. Phosphorylation of serine residues onthe I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. ActivatedNFKB complex translocates into the nucleus and binds DNA atkappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or Gpurine; and Y is a C or T pyrimidine).

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

Polyclonal

Homo sapiens