ZIP7 Antibody

ArtNr	PRS-6093-0.1mg
Hersteller	ProSci
Menge	0.1 mg
Quantity options	0.02 mg 0.1 mg
Kategorie	Oncology Antibodies Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies By Organ Colorectal Cancer
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	Dufner-Beattie et al. J. Biol. Chem.2003; 278:50142-50. Eide. Pflugers Arch.2004; 447:796-800. Taylor and Nicohlson. Biochim. Biophys. Acta.2003; 1611:16-30. Lai et al. Genomics1994; 23:338-42.
NCBI	SLC39A7
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ZIP7 Antibody: KE4,HKE4,ZIP7,RING5,H2-KE4,D6S115E,D6S2244E,Zinc transporter SLC39A7,Histidine-rich membrane protein Ke4
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Primary Antibodies
Shipping Temperature	Blue Ice
Storage Conditions	ZIP7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight	Predicted: 50kD Observed: 50kD
Manufacturer - Research Area	Cancer, Cell Cycle
Background	ZIP7 Antibody: The zinc transporter ZIP7, also known as SLC39A7, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP7 was initially identified while characterizing genes in the major histocompatibility complex on chromosome 17. ZIP7 mRNA is abundantly and widely expressed and the protein localizes to the Golgi apparatus. It functions to transport intracellular zinc from the Golgi apparatus to the cytoplasm of the cell. ZIP7 expression is expressed by zinc. ZIP7 has been suggested to act a hub for tyrosine kinase activation and may thus be a potential therapeutic target for diseases such as cancer where prevention of tyrosine kinase activation would be advantageous.
By Type	Cancer, Cell Cycle
Badges	Trial Size
Modifications	None
Protein Gi #	117553619
Purification	ZIP7 Antibody is affinity chromatography purified via peptide column.
Isoforms	Human ZIP7 has one isoform (469aa, 50kD). Mouse ZIP7 has one isoform (476aa, 51kD) and Rat ZIP7 also has one isoform (468aa, 50kD). 6093 can detect human, mouse and rat.
Validation	Independent Antibody Validation in Cell lines (Figure 1) shows similar ZIP7 expression profile in human cell lines detected by two independent anti-ZIP7 antibodies that recognize different epitopes, 6093 against N-terminus domain and 24-029 against recombinant fusion protein. ZIP7 proteins are detected in all tested cell lines at different expression levels by the two independent antibodies.
Positive Control 1	PRS-1403-0.1mg
Positive Control 2	PRS-10-301-4um
Positive Control 3	PRS-1204-0.1mg
Positive Control 4	PRS-1212-0.1mg
Concentration	1 mg/mL
Buffer	ZIP7 Antibody is supplied in PBS containing 0.02% sodium azide.
Application Note	WB: 0.5-1 μ g/mL; IHC: 2.5 μ g/mL; IF: 20 μ g/mL. Antibody validated: Western Blot in human, mouse and rat samples; Immunohistochemistry in human samples; Immunofluorescence in human samples. All other applications and species not yet tested.
Immunogen	Anti-ZIP7 antibody (6093) was raised against a peptide corresponding to 17 amino acids near the amino terminus of human ZIP7. The immunogen is located within amino acids 20-70 of ZIP7.
Clonality	Polyclonal
NCBI Official Name	solute carrier family 39 (zinc transporter), member 7
NCBI Organism	Homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher.

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Menge: 0.1 mg

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