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IGF1R Antibody

IGF1R Antibody

Hersteller	ProSci
Kategorie	Oncology Neuroscience Neural Lineage Markers Neural Signaling Neural Adhesion Molecules Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Sarcoma Flow Cytometry Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies Astrocytoma Calcium Binding Protein Markers Interneuron Markers
Typ	Antibody Polyclonal
Specific against	Human
Format	Liquid
Applikationen	WB, FC, IF, IHC-P
Menge	400 ul
Host	Rabbit
ArtNr	PRS-63-098-400ul
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
Shipping	blue ice or RT
By Research Area	Cancer, Cell Cycle, Neuroscience, Signal Transduction
Homology	Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen	This IGF1R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-77 amino acids from the N-terminal region of human IGF1R.
Applications	For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:50~100 For FACS starting dilution is: 1:10~50 For IF starting dilution is: 1:10~50
Predicted Molecular Weight	155 kDa
Purification	This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Clonality	Polyclonal
Isotype	Rabbit Ig
Conjugate	Unconjugated
Buffer	Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration	batch dependent
Storage Conditions	Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	IGF1R
Accession #	P08069
Protein Gi #	124240
Ncbi Gene Id #	3480
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	IGF1R
Ncbi Official Full Name	Insulin-like growth factor 1 receptor
Ncbi Organism	Homo sapiens
Swissprot #	P08069
Background	The IGF1R receptor binds insulin-like growth factor with a high affinity and plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. The protein possess tyrosine kinase activity.
Background References 1	Song, R.X., et al., Proc. Natl. Acad. Sci. U.S.A. 101(7):2076-2081 (2004).
Background References 2	Zhao, H., et al., Oncogene 23(3):786-794 (2004).
Background References 3	Lu, Y., et al., Biochem. Biophys. Res. Commun. 313(3):709-715 (2004).
Background References 4	Hakam, A., et al., Dig. Dis. Sci. 48(10):1972-1978 (2003).
1st Image Caption	Western blot analysis of IGF1R Antibody (N-term K66) in WiDr cell line lysates (35ug/lane)
2nd Image Caption	IGF1R Antibody (N-term K66) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the IGF1R Antibody (N-term K66) for immunohistochemistry.
3rd Image Caption	Flow cytometric analysis of WiDr cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
4th Image Caption	Confocal immunofluorescent analysis of IGF1R Antibody (N-term K66) with WiDr cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 400 ul

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Lieferung vsl. bis 06.06.2024

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