Anti-Rho Antibody (Phospho-S188) (OAAI00595)

ca.24 kDa

387

Ras homolog gene family consists of RhoA, RhoB, RhC proteins. These proteins interact directly with protein kinase (Rho kinase) to serve as downstream effectors of the activated GTPase. The Rho proteins are involved in the regulation of the actin cytosekeleton. Activation of Rho to the GTP bound state promotes formation of stress fibers and is required for the formation and maintenance of focal adhesions. Pathways stimulated by cytokines, hormones and various forms of stress utilize p21 proteins of the Rho family. Possible mediators for these responses include protein kinase such as p120PKN, and p150, ROKalpha/Rho-A kinase, myosin light chain (MLC), phosphatase and PIP 5-kinase.

Polyclonal

Wet Ice