Rabbit anti-human Ryanodine receptor 1 (OACA00808)

Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca2+ leaking into the cytoplasm. Can also mediate the release of Ca2+ from intracellular stores in neurons, and may thereby promote prolonged Ca2+ signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis

CCO, MHS, RYR, MHS1, RYDR, SKRR, RYR-1

Shipped at 4°, C. Upon delivery aliquot and store at -20°, C or -80°, C. Avoid repeated freeze.

Biotin-conjugated