APOA5 Antibody (OAEC04241)

APOA5

116519

Apolipoprotein A5 (ApoA5) is fas t gaining attention as a key regulator of serum triglyceride concentrations. An ApoA5 mouse knock-out model produced an approxim ately four fold increase in serum triglycerides, whereas a knock-in model with human ApoA5 produced50-70% lower concentrations of mouse serum triglycerides. In addition, peroxis ome proliferator-activated receptor-_ agonists, which are used clinically to lower serum triglyceride concentrations, cause increased ApoA5 mRNA expression. Recently, it was demonstrated that ApoA5 is present in human serum detected by polyclonal antibodies against both the NH2 and COOH termini, although at much lower concentration than other apolipoproteins

Purified recombinant fragment of human APOA5 expres sed in EColi.