TMED10 Antibody (OAGA05080)

transmembrane emp24 domain-containing protein 10

10972

This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex' s gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer' s disease. This gene has a pseudogene on chromosome 8.

Polyclonal

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