EIF4G1 Antibody (Phospho-Ser1232) (OALA08393)

eukaryotic translation initiation factor 4 gamma 1

1981

The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5' -terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage.

Polyclonal

Synthesized non-phosphopeptide derived from human eIF4G around the phosphorylation site of serine 1232 (P-V-SP-P-L)