REG3G ELISA Kit (Mouse) (OKCD00733)

regenerating islet-derived protein 3-gamma

19695

Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury.7 Publications < p>Manually curated information for which there is published experimental evidence.< /p> < p>< a href="/manual/evidences#ECO:0000269">Moreâa‚¬A< /a>< /p> Manual assertion based on experiment iniRef.3"Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment."_x005F_x000D_ Mukherjee S., Partch C.L., Lehotzky R.E., Whitham C.V., Chu H., Bevins C.L., Gardner K.H., Hooper L.V._x005F_x000D_ J. Biol. Chem. 284:4881-4888(2009) [PubMed] [Europe PMC] [Abstract]Cited for: PROTEIN SEQUENCE OF N-TERMINUS, FUNCTION, PROTEOLYTIC PROCESSING.Ref.4"Refolding, purification, and characterization of human and murine RegIII proteins expressed in Escherichia coli."_x005F_x000D_ Cash H.L., Whitham C.V., Hooper L.V._x005F_x000D_ Protein Expr. Purif. 48:151-159(2006) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, TISSUE SPECIFICITY.Ref.5"Symbiotic bacteria direct expression of an intestinal bactericidal lectin."_x005F_x000D_ Cash H.L., Whitham C.V., Behrendt C.L., Hooper L.V._x005F_x000D_ Science 313:1126-1130(2006) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, MANNAN- AND PEPTIDOGLYCAN-BINDING, TISSUE SPECIFICITY, INDUCTION, DEVELOPMENTAL STAGE.Ref.6"MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection."_x005F_x000D_ Brandl K., Plitas G., Schnabl B., DeMatteo R.P., Pamer E.G._x005F_x000D_ J. Exp. Med. 204:1891-1900(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY.Ref.8"The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine."_x005F_x000D_ Vaishnava S., Yamamoto M., Severson K.M., Ruhn K.A., Yu X., Koren O., Ley R., Wakeland E.K., Hooper L.V._x005F_x000D_ Science 334:255-258(2011) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.Ref.9"The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury."_x005F_x000D_ Lai Y., Li D., Li C., Muehleisen B., Radek K.A., Park H.J., Jiang Z., Li Z., Lei H., Quan Y., Zhang T., Wu Y., Kotol P., Morizane S., Hata T.R., Iwatsuki K., Tang C., Gallo R.L._x005F_x000D_ Immunity 37:74-84(2012) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY.Ref.10"Innate Stat3-mediated induction of the antimicrobial protein Reg3gamma is required for host defense against MRSA pneumonia."_x005F_x000D_ Choi S.M., McAleer J.P., Zheng M., Pociask D.A., Kaplan M.H., Qin S., Reinhart T.A., Kolls J.K._x005F_x000D_ J. Exp. Med. 210:551-561(2013) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY.

< 11.7 pg/mL