CILP Recombinant Protein

Protein

Root Catalog/Products/Recombinant Proteins

60kDa

cartilage intermediate layer protein, nucleotide pyrophosphohydrolase

Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.

Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage (By similarity).

NP_775561.1

PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.