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Recombinant Human Fructose-1,6-bisphosphatase 1 (FBP1)

Recombinant Human Fructose-1,6-bisphosphatase 1 (FBP1)

ArtNr	BM-RPC26085-50ug
Hersteller	Biomatik
Menge	50ug
Kategorie	Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Specific against	Human (Homo sapiens)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 (Liver FBPase) (FBPase 1) (FBP)
Similar products	D-fructose-1, 6-bisphosphate 1-phosphohydrolase 1 (Liver FBPase) (FBPase 1) (FBP)
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Gene Name	FBP1
Alternative Names	D-fructose-1, 6-bisphosphate 1-phosphohydrolase 1 (Liver FBPase) (FBPase 1) (FBP)
Uniprot	P09467
Source	E.coli
Expression Region	2-338aa
AA Sequence	ADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLN SLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQV KKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIV EPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYR KKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVL AMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYS LNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYV GSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYE CNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAP VILGSPDDVLEFLKVYEKHSAQ
Sequence Info	Full Length of Mature Protein
Tag Info	N-terminal 10xHis-tagged and C-terminal Myc-tagged
Theoretical MW	41.7 kDa
Purity	>85% as determined by SDS-PAGE.
Storage Buffer	Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Endotoxin Level	Not tested
Biological Activity	Not tested
Shipping Condition	Ice packs
Storage	Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles.
Expiry Date	1 year
Restriction	For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.
Relevance	Catalyzes the hydrolysis of fructose 1, 6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
Function	Catalyzes the hydrolysis of fructose 1, 6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
Involvement in disease	Fructose-1, 6-bisphosphatase deficiency (FBP1D)
Protein Families	FBPase class 1 family
Tissue Specificity	Expressed in pancreatic islets.
Paythway	AMPKSignaling

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