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Recombinant Human VEGF coregulated chemokine 1 protein (CXCL17) (Active)

Recombinant Human VEGF coregulated chemokine 1 protein (CXCL17) (Active)

ArtNr	BM-RPC26580-100ug
Hersteller	Biomatik
Menge	100ug
Kategorie	Oncology By Cell Type Carcinoma Peptides & Proteins Recombinant Proteins Cell Biology Cell Culture Cytokines Adenocarcinoma By Organ Bladder Cancer
Typ	Proteins Recombinant
Specific against	Human (Homo sapiens)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	C-X-C motif chemokine 17, DMC
Similar products	DMC, C-X-C motif chemokine 17
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Gene Name	CXCL17, VCC1, UNQ473/PRO842
Alternative Names	C-X-C motif chemokine 17, DMC
Uniprot	Q6UXB2
Source	E.coli
Expression Region	22-119aa
AA Sequence	SSLNPGVARG HRDRGQASRR WLQEGGQECE CK DWFLRAPR RKFMTVSGLP KKQCPCDHFK GNVK KTRHQR HHRKPNKHSR ACQQFLKQCQ LRSFAL PL
Sequence Info	Full Length of Mature Protein
Tag Info	Tag-Free
Theoretical MW	11.5 kDa
Purity	>96% as determined by SDS-PAGE and HPLC.
Storage Buffer	Lyophilized from a 0.2 um filtered PBS, pH 7.4
Endotoxin Level	Less than 1.0 EU/ug as determined by LAL method.
Biological Activity	The ED50 as determined by its ability to induce VEGF expression using murine endothelial cells is less than 5.0 ug/ml, corresponding to a specific activity of ? 200 IU/mg.
Shipping Condition	Ice packs
Storage	Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles.
Expiry Date	1 year
Restriction	For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.
Relevance	Plays a role in angiogenesis and possibly in the development of tumors. May be a housekeeping chemokine regulating recruitment of nonactivated blood monocytes and immature dendritic cells into tissues. May play a role in the innate defense against infections. {ECO:0000269\|PubMed:16455961, ECO:0000269\|PubMed:16989774, ECO:0000269\|PubMed:17307946}.
Function	Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells
Subcellular location	Secreted
Protein Families	Intercrine alpha (chemokine CxC) family
Tissue Specificity	Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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