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Recombinant Human Tumor necrosis factor receptor superfamily member 17 protein (TNFRSF17), partial (Active)

Recombinant Human Tumor necrosis factor receptor superfamily member 17 protein (TNFRSF17), partial (Active)

ArtNr	BM-RPC26710-100ug
Hersteller	Biomatik
Menge	100ug
Kategorie	Oncology Neuroscience Neuroinflammation Metabolism Diabetes By Cell Type Hematology Myeloma Peptides & Proteins Recombinant Proteins Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis
Typ	Proteins Recombinant
Specific against	Human (Homo sapiens)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	B-cell maturation protein,
Similar products	B-cell maturation protein
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Gene Name	TNFRSF17, BCM, BCMA
Alternative Names	B-cell maturation protein,
Uniprot	Q02223
Source	E.coli
Expression Region	5-54aa
AA Sequence	AGQCSQNEYF DSLLHACIPC QLRCSSNTPP LT CQRYCNAS VTNSVKGTNA
Sequence Info	Partial
Tag Info	Tag-Free
Theoretical MW	5.4 kDa
Purity	>98% as determined by SDS-PAGE and HPLC.
Storage Buffer	Lyophilized from a 0.2 um filtered 30 % acetonitrile, 0.1 % TFA
Endotoxin Level	Less than 1.0 EU/ug as determined by LAL method.
Biological Activity	The ED50 as determined by its ability to inhibit APRIL-mediated proliferation of anti-IgM stimulated murine B cells is no less than 40 ng/ml, corresponding to a specific activity of ? 2.5 x 104 IU/mg in the presence of 100 ng/ml human APRIL.
Shipping Condition	Ice packs
Storage	Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles.
Expiry Date	1 year
Restriction	For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.
Relevance	Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. {ECO:0000269\|PubMed:10801128, ECO:0000269\|PubMed:10903733, ECO:0000269\|PubMed:10973284}.
Function	Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
Involvement in disease	A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4; 16)(q26; p13) with IL2.
Subcellular location	Cell membrane, Single-pass type III membrane protein, Endomembrane system, Single-pass type III membrane protein
Tissue Specificity	Expressed in mature B-cells, but not in T-cells or monocytes.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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