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Recombinant Human Tumor necrosis factor receptor superfamily member 1A protein (TNFRSF1A) (Active)

Recombinant Human Tumor necrosis factor receptor superfamily member 1A protein (TNFRSF1A) (Active)

ArtNr	BM-RPC26717-1mg
Hersteller	Biomatik
Menge	1mg
Kategorie	Oncology Neuroscience Neuroinflammation Metabolism Diabetes By Cell Type Hematology Leukemia Peptides & Proteins Recombinant Proteins Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis
Typ	Proteins Recombinant
Specific against	Human (Homo sapiens)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Tumor necrosis factor receptor 1, Tumor necrosis factor receptor type I, TNF-RI, TNFR-I, p55
Similar products	p55, Tumor necrosis factor receptor 1, Tumor necrosis factor receptor type I, TNF-RI, TNFR-I
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Gene Name	TNFRSF1A, TNFAR, TNFR1
Alternative Names	Tumor necrosis factor receptor 1, Tumor necrosis factor receptor type I, TNF-RI, TNFR-I, p55
Uniprot	P19438
Source	E.coli
Expression Region	22-211aa
AA Sequence	IYPSGVIGLV PHLGDREKRD SVCPQGKYIH PQ NNSICCTK CHKGTYLYND CPGPGQDTDC RECE SGSFTA SENHLRHCLS CSKCRKEMGQ VEISSC TVDR DTVCGCRKNQ YRHYWSENLF QCFNCSLC LN GTVHLSCQEK QNTVCTCHAG FFLRENECVS CSNCKKSLEC TKLCLPQIEN VKGTEDSGTT
Sequence Info	Partial
Tag Info	Tag-Free
Theoretical MW	21.2 kDa
Purity	>97% as determined by SDS-PAGE and HPLC.
Storage Buffer	Lyophilized from a 0.2 um filtered PBS, pH 7.4
Endotoxin Level	Less than 1.0 EU/ug as determined by LAL method.
Biological Activity	The ED50 as determined by its ability to inhibit the TNF-alpha mediated cytotoxicity in the L-929 cells is less than 0.05 ug/ml, corresponding to a specific activity of ? 2 x 104 IU/mg in the presence of 0.25 ng/mL of rHuTNF-alpha.
Shipping Condition	Ice packs
Storage	Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles.
Expiry Date	1 year
Restriction	For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.
Relevance	Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Function	Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Involvement in disease	Familial hibernian fever (FHF); Multiple sclerosis 5 (MS5)
Subcellular location	Cell membrane, Single-pass type I membrane protein, Golgi apparatus membrane, Single-pass type I membrane protein, Secreted, Note=A secreted form is produced through proteolytic processing, SUBCELLULAR LOCATION: Isoform 4: Secreted
Paythway	MAPKsignalingpathway

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 1mg

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Lieferung vsl. bis 04.09.2025

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