Anti-MITF Antibody

ArtNr	BOS-A00269-1
Hersteller	Boster
Menge	100 ul
Quantity options	100 ul 100 ul/vial 200 ul 50 ul
Kategorie	Oncology By Cell Type Melanoma Western Blot
Format	Liquid
Applikationen	WB
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Alias	Microphthalmia-associated transcription factor,Class E basic helix-loop-helix protein 32,bHLHe32,MITF,BHLHE32
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Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Molecular Weight	58795 MW
Clonality	Polyclonal
Application Details	WB: 1:500-1:2000
Gene Name	MITF
Gene Full Name	Microphthalmia-associated transcription factor
Immunogen	Recombinant fusion protein of human MITF(NP_937801.1).
Contents	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Concentration	1 mg/ml
Protein Name	Microphthalmia-associated transcription factor
Protein Function	Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.
Subcellular Localization	Nucleus
Description	Boster Bio Anti-MITF Antibody catalog # A00269-1. Tested in WB applications. This antibody reacts with Human, Mouse.
Tissue Specificity	Isoform M is exclusively expressed in melanocytes and melanoma cells. Isoform A and isoform H are widely expressed in many cell types including melanocytes and retinal pigment epithelium (RPE). Isoform C is expressed in many cell types including RPE but not in melanocyte-lineage cells. Isoform Mdel is widely expressed in melanocytes, melanoma cell lines and tissues, but almost undetectable in non-melanoma cell lines.

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BOS-A00269-1-datasheet.pdf

BOS-A00269-1-safety-datasheet.pdf