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Anti-MITF Antibody

Anti-MITF Antibody

Item no.	BOS-A00269-1
Manufacturer	Boster
Amount	100 ul
Quantity options	100 ul 100 ul/vial 200 ul 50 ul
Category	Oncology By Cell Type Melanoma Western Blot
Format	Liquid
Applications	WB
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Alias	Microphthalmia-associated transcription factor,Class E basic helix-loop-helix protein 32,bHLHe32,MITF,BHLHE32
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Molecular Weight	58795 MW
Clonality	Polyclonal
Application Details	WB: 1:500-1:2000
Gene Name	MITF
Gene Full Name	Microphthalmia-associated transcription factor
Immunogen	Recombinant fusion protein of human MITF(NP_937801.1).
Contents	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Concentration	1 mg/ml
Protein Name	Microphthalmia-associated transcription factor
Protein Function	Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.
Subcellular Localization	Nucleus
Description	Boster Bio Anti-MITF Antibody catalog # A00269-1. Tested in WB applications. This antibody reacts with Human, Mouse.
Tissue Specificity	Isoform M is exclusively expressed in melanocytes and melanoma cells. Isoform A and isoform H are widely expressed in many cell types including melanocytes and retinal pigment epithelium (RPE). Isoform C is expressed in many cell types including RPE but not in melanocyte-lineage cells. Isoform Mdel is widely expressed in melanocytes, melanoma cell lines and tissues, but almost undetectable in non-melanoma cell lines.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-A00269-1-datasheet.pdf

BOS-A00269-1-safety-datasheet.pdf