Anti-PHOX2B Antibody

ArtNr	BOS-A02221
Hersteller	Boster
Menge	0.1 mg
Quantity options	0.1 mg 100 ul
Kategorie	Oncology Western Blot ELISA By Organ Brain Cancer Nervous System Cancer Immunostaining
Format	Liquid
Applikationen	WB, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Alias	PMX2B,NBLST2,NBPhox,PMX2B,Paired mesoderm homeobox protein 2B,Neuroblastoma Phox
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	PHOX2B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight	31621 MW
Clonality	Polyclonal
Application Details	PHOX2B antibody can be used for detection of PHOX2B by Western blot at 1 - 2 μg/mL. Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Gene Name	PHOX2B
Gene Full Name	Paired-like homeobox 2b
Manufacturer - Specificity	PHOX2B antibody is predicted to not cross-react with other paired homeobox family members.
Background	PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.
Immunogen	PHOX2B antibody was raised against a 15 amino acid synthetic peptide near the center of human PHOX2B. The immunogen is located within amino acids 130 - 180 of PHOX2B.
Contents	PHOX2B Antibody is supplied in PBS containing 0.02% sodium azide.
Purification	PHOX2B Antibody is affinity chromatography purified via peptide column.
Concentration	1 mg/mL
Manufacturer - Research Category	Stem Cells
Protein Name	Paired-like homeobox 2b
Protein Function	Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum- response element.
Subcellular Localization	Nucleus
Description	Boster Bio Anti-PHOX2B Antibody (Catalog # A02221). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Expressed in neuroblastoma, brain and adrenal gland.
Predicted Reactivity	Chicken, Bovine
Manufacturer - Cross Reactivity	PHOX2B antibody is predicted to not cross-react with other paired homeobox family members.

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BOS-A02221-datasheet.pdf

BOS-A02221-safety-datasheet.pdf