Anti-TEF-1 TEAD1 Antibody

Primary Antibodies

47946 MW

WB: 1:500-1:2000
IHC: 1:50-1:200
ICC/IF: 1:50-1:200
ChIP: 1:20-1:50

Transcriptional enhancer factor TEF-1

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Transcription factor which plays a key role in the Hippo
signaling pathway, a pathway involved in organ size control and
tumor suppression by restricting proliferation and promoting
apoptosis. The core of this pathway is composed of a kinase
cascade wherein MST1/MST2, in complex with its regulatory protein
SAV1, phosphorylates and activates LATS1/2 in complex with its
regulatory protein MOB1, which in turn phosphorylates and
inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene
expression of YAP1 and WWTR1/TAZ, thereby regulating cell
proliferation, migration and epithelial mesenchymal transition
(EMT) induction. Binds specifically and cooperatively to the SPH
and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates
transcription in vivo in a cell-specific manner. The activation
function appears to be mediated by a limiting cell-specific
transcriptional intermediary factor (TIF). Involved in cardiac
development. Binds to the M-CAT motif.

Boster Bio Anti-TEF-1 TEAD1 Antibody catalog # A03263. Tested in WB, IHC, ICC/IF, ChIP applications. This antibody reacts with Human, Mouse, Rat.