Anti-IFIT3 Antibody

Primary Antibodies

55985 MW

WB: 1:500-1:1000
IHC: 1:100-1:200
IF: 1:50-1:200

Interferon-induced protein with tetratricopeptide repeats 3

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

IFN-induced antiviral protein which acts as an inhibitor
of cellular as well as viral processes, cell migration,
proliferation, signaling, and viral replication. Enhances MAVS-
mediated host antiviral responses by serving as an adapter
bridging TBK1 to MAVS which leads to the activation of TBK1 and
phosphorylation of IRF3 and phosphorylated IRF3 translocates into
nucleus to promote antiviral gene transcription. Exihibits an
antiproliferative activity via the up-regulation of cell cycle
negative regulators CDKN1A/p21 and CDKN1B/p27. Normally,
CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27
in the nucleus and exports it to the cytoplasm for ubiquitin-
dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm,
thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates
CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can
negatively regulate the apoptotic effects of IFIT2.

Boster Bio Anti-IFIT3 Antibody catalog # A03920-1. Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.

Interferon-induced protein with tetratricopeptide repeats 3, IFIT-3, CIG49, ISG-60, Interferon-induced 60 kDa protein, IFI-60K, Interferon-induced protein with tetratricopeptide repeats 4, IFIT-4, Retinoic acid-induced gene G protein, P60, RIG-G, IFIT3, CIG-49, IFI60, IFIT4, ISG60