Anti-IFIT3 Antibody

ArtNr	BOS-A03920
Hersteller	Boster
Menge	0.1 mg
Quantity options	0.1 mg 100 ul 100 ul/vial
Kategorie	Oncology By Cell Type Melanoma Immunohistochemistry Western Blot ELISA Immunostaining
Format	Liquid
Applikationen	WB, ELISA, IHC-P
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Alias	P60,IRG2,IFI60,IFIT4,ISG60,RIG-G,CIG-49,GARG-49,Interferon-induced protein with tetratricopeptide repeats 3,CIG49,IFIT-3
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	IFIT3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Molecular Weight	55985 MW
Clonality	Polyclonal
Application Details	IFIT3 antibody can be used for detection of IFIT3 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry at 5 μg/mL. Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Gene Name	IFIT3
Gene Full Name	Interferon-induced protein with tetratricopeptide repeats 3
Manufacturer - Specificity	IFIT3 antibody is human specific. This antibody is predicted to not cross-react with other members of the IFIT protein family.
Background	The interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) protein is a member of a family of tetratricopeptide repeat-containing proteins whose transcription is upregulated by interferons, virus infection, and molecular patterns such as dsRNA or lipopolysaccharides (1, 2). These proteins have been suggested to induce anti-viral cellular activities in response to infection (2). IFIT3 has been shown to interact with TBK1 following RNA virus infection, thereby bridging TBK1 to VISA on the mitochondrion and activating IRF3 and thus the immune response (3).
Immunogen	IFIT3 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human IFIT3. The immunogen is located within amino acids 380 - 430 of IFIT3.
Contents	IFIT3 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification	IFIT3 antibody is affinity chromatography purified via peptide column.
Concentration	1 mg/mL
Manufacturer - Research Category	Innate Immunity
Protein Name	Interferon-induced protein with tetratricopeptide repeats 3
Protein Function	IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin- dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.
Subcellular Localization	Cytoplasm. Mitochondrion.
Description	Boster Bio Anti-IFIT3 Antibody (Catalog # A03920). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human.
Tissue Specificity	Expression significantly higher in peripheral blood mononuclear cells (PBMCs) and monocytes from systemic lupus erythematosus (SLE) patients than in those from healthy individuals (at protein level). Spleen, lung, leukocytes, lymph nodes, placenta, bone marrow and fetal liver.
Manufacturer - Cross Reactivity	IFIT3 antibody is human specific. This antibody is predicted to not cross-react with other members of the IFIT protein family.

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BOS-A03920-datasheet.pdf

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