Anti-USP19 Antibody

Primary Antibodies

145651 MW

WB: 1:500-1:1000
IHC: 1:50-1:200

Ubiquitin carboxyl-terminal hydrolase 19

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Deubiquitinating enzyme that regulates the degradation
of various proteins. Deubiquitinates and prevents proteasomal
degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-
dependent degradation thereby playing a role in cell
proliferation. Involved in decreased protein synthesis in
atrophying skeletal muscle. Modulates transcription of major
myofibrillar proteins. Also involved in turnover of endoplasmic-
reticulum-associated degradation (ERAD) substrates. Regulates the
stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their
ubiquitination. Required for cells to mount an appropriate
response to hypoxia and rescues HIF1A from degradation in a non-
catalytic manner. Plays an important role in 17 beta-estradiol
(E2)-inhibited myogenesis. Decreases the levels of ubiquitinated
proteins during skeletal muscle formation and acts to repress
myogenesis. Exhibits a preference towards 'Lys-63'-linked
ubiquitin chains.

Boster Bio Anti-USP19 Antibody catalog # A05870-2. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.