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Anti-ARHGAP18 Antibody

Anti-ARHGAP18 Antibody

ArtNr	BOS-A08418-1
Hersteller	Boster
Menge	0.1 mg
Format	Liquid
Applikationen	WB, IF, ICC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Alias	SENEX, MacGAP, bA307O14.2, Rho GTPase-activating protein 18
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	ARHGAP18 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Observed Molecular Weight	74977 MW
Clonality	Polyclonal
Application Details	ARHGAP18 antibody can be used for detection of ARHGAP18 by Western blot at 1 - 2 ?g/mL. Antibody can also be used for immunocytochemistry starting at 2.5 ?g/mL. For immunofluorescence start at 20 ?g/mL. Antibody validated: Western Blot in mouse samples; Immunocytochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Manufacturer - Gene Name	ARHGAP18
Gene Full Name	Rho GTPase activating protein 18
Background	ARHGAP18 is one member of the human RhoGAP family with approximately 80 RhoGAP proteins known to be encoded in the human genome. Rho proteins belong to the Ras superfamily that is composed of over 50 members divided into six families, including Ras, Sar, Rho, Ran, Rab and Arf. Rho GTPases are important regulators of the actin cytoskeleton and consequently influence the shape and migration of cells. ARHGAP18 is linked to Ras, and thus, to EGFR-mediated proliferation, migration and differentiation. ARHGAP18 is precisely contained within chromosome 6q22-24, which has been shown to be linked to schizophrenia, suggesting that ARHGEP18 may play a role in this condition.
Immunogen	ARHGAP18 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ARHGAP18. The immunogen is located within the last 50 amino acids of ARHGAP18.
Contents	ARHGAP18 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification	ARHGAP18 Antibody is affinity chromatography purified via peptide column.
Concentration	1 mg/mL
Manufacturer - Research Category	Signal Transduction
Protein Name	Rho GTPase activating protein 18
Protein Function	Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595).
Subcellular Localization	Cytoplasm
Short Description	Boster Bio Anti-ARHGAP18 Antibody (Catalog # A08418-1). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.
Description	Boster Bio Anti-ARHGAP18 Antibody (Catalog # A08418-1). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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BOS-A08418-1-datasheet.pdf

BOS-A08418-1-safety-datasheet.pdf