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Anti-STIM1 Purified Monoclonal Antibody

Anti-STIM1 Purified Monoclonal Antibody

ArtNr	BOS-M00312-1
Hersteller	Boster
Menge	0.1 mg
Format	Liquid
Applikationen	WB, IP, ICC, IHC-P
Clon	CDN3H4
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Mouse
Isotype	IgG1
Alias	GOK, TAM1, STRMK
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Manufacturer - Category	Primary Antibodies, Monoclonal Antibodies
Manufacturer - Isotype	Mouse IgG1
Storage Conditions	Store at 2-8°C. Do not freeze.
Clonality	Monoclonal
Application Details	Immunocytochemistry: Methanol-aceton fixation; positive control: HeLa human cervix carcinoma cell line. Immunohistochemistry (paraffin sections): 5 ?g/ml. Western blotting: 1 ?g/ml; positive control: RBL rat basophilic leukemia cell line; both reducing and non-reducing conditions.
Manufacturer - Gene Name	STIM1
Gene Full Name	Stromal interaction molecule 1
Background	STIM1 (stromal interacting molecule; also known as GOK) acts as a sensor of calcium depletion within the endoplasmic reticulum and transduces the signal to Orai1, the presumptive CRAC channel at the plasma membrane. Following decrease of luminal calcium concentration, STIM1 oligomerizes and induces Orai1 to enable entry of extracellular calcium into the cytoplasm. However, the precise mechanism of STIM1-Orai1 interaction has not been elucidated yet. Many questions also remain to be solved around STIM1 functional distribution. It turns out that STIM1 associates with growing ends of microtubules and is involved in endoplasmic reticulum tubule extension.
Immunogen	Synthetized peptide (C-terminal cytoplasmic part of STIM1). The mouse monoclonal antibody CDN3H4 reacts with a cytoplasmic epitope of human and rodent STIM1, a 84 kDa essential and conserved regulator of store-operated Ca2+ channel function.
Contents	Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Purification	Purified by protein-A affinity chromatography.
Concentration	1 mg/ml
Short Description	Boster Bio Anti-STIM1 Purified Monoclonal Antibody (Catalog# M00312-1). Tested in IP, WB, IHC-P, ICC application(s). This antibody reacts with Rat, Human, Mouse.
Description	Boster Bio Anti-STIM1 Purified Monoclonal Antibody (Catalog# M00312-1). Tested in IP, WB, IHC-P, ICC application(s). This antibody reacts with Rat, Human, Mouse.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

BOS-M00312-1-datasheet.pdf

BOS-M00312-1-safety-datasheet.pdf