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Anti-Bonzo/CXCR6 Antibody Picoband® Europäischer Partner

ArtNr BOS-PA2082-FITC
Hersteller Boster
Menge 100 ug
Quantity options 100 ug/vial 10 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug
Kategorie
Typ Antibody Polyclonal
Format Lyophilized
Applikationen WB, IHC
Specific against Human (Homo sapiens)
Host Rabbit
Isotype IgG
Konjugat/Tag FITC
Sensitivity >5000 cells
Sequence Belongs to the G-protein coupled receptor 1 family.
Citations 1. Kim, C. H., Kunkel, E. J., Boisvert, J., Johnston, B., Campbell, J. J., Genovese, M. C., Greenberg, H. B., Butcher, E. C. Bonzo/CXCR6 expression defines type 1-polarized T-cell subsets with extralymphoid tissue homing potential. J. Clin. Invest. 107: 595-601, 2001.
2. Liao, F., Alkhatib, G., Peden, K. W. C., Sharma, G., Berger, E. A., Farber, J. M. STRL33, a novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. J. Exp. Med. 185: 2015-2023, 1997.
3. Matloubian, M., David, A., Engel, S., Ryan, J. E., Cyster, J. G. A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nature Immun. 1: 298-304, 2000.
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias C-X-C chemokine receptor type 6,CXC-R6,CXCR-6,CDw186,G-protein coupled receptor STRL33,G-protein coupled receptor bonzo,CD186,CXCR6,BONZO,STRL33,TYMSTR
Lieferbar
Manufacturer - Category
Primary Antibodies
Storage Conditions
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular weight
39 kDa
Calculated Molecular weight
39280 MW
Clonality
Polyclonal
Application Details
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human
Western blot, 0.1-0.5μg/ml, Human
Gene Name
CXCR6
Gene Full Name
C-X-C chemokine receptor type 6
Manufacturer - Specificity
No cross reactivity with other proteins.
Background
CXCR6 (Chemokine, CXC Motif, Receptor 6), also known as STRL33, is a protein that in humans is encoded by the CXCR6 gene. By Southern blot analysis of genomic DNA and somatic cell hybrid analysis, Liao et al. (1997) mapped the single-copy STRL33 gene to chromosome 3. Matloubian et al. (2000) found that human and mouse cells expressing CXCR6 showed a strong chemotactic response to CXCL16 but not to other chemokines. The authors concluded that CXCL16 and CXCR6 probably function in interactions between dendritic cells and T cells and in regulating T-cell migration in the splenic red pulp. Kim et al. (2001) concluded that CXCR6 may be important in the trafficking of effector T cells mediating type-1 inflammation.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Bonzo, different from the related mouse and rat sequences by three amino acids.
Contents
Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2mg Na2HPO4, 0.05 mg NaN3.
Purification
Immunogen affinity purified.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Concentration
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category
Antiviral Signaling, Host-Virus Interaction, Immune System Diseases, Immunology, Interspecies Interaction, Microbiology
Protein Name
C-X-C chemokine receptor type 6
Protein Function
Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.
Subcellular Localization
Cell membrane; Multi-pass membrane protein.
Description
Boster Bio Anti-Bonzo/CXCR6 Antibody catalog # PA2082. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity
Expressed in lymphoid tissues and activated T cells.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Manufacturer - Cross Reactivity
No cross-reactivity with other proteins

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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