Human recombinant IL-21 (Interleukin-21) protein, AF

His Tag (C-term)

The protein has a calculated MW of 16.2 kDa.
The protein migrates as 20 kDa under reducing condition (SDS-PAGE analysis).

The protein has a calculated MW of 16.2 kDa.The protein migrates as 20 kDa under reducing condition (SDS-PAGE analysis).

>95% as determined by SDS-PAGE.

Interleukin-21 (IL-21) belongs to the IL-15/IL-21 family, which exerts pleiotropic immune regulations. IL-21 produced primarily by natural killer T (NKT) cells, T follicular helper (TFH) cells and TH17 cells. As a pleiotropic cytokine, IL-21 has been shown to regulate both innate and humoral immunity. It has potent inhibitory activity towards the activation and maturation of granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced dendritic cells (DCs). In B cells, IL-21 has a major role in the development of immunoglobulin responses. In T cells, it is required to facilitate the functional differentiation of several CD4+ T cell subsets. In addition, the ability of IL-21 to enhance the cytotoxic activity of both CD8+ T cells and NK cells makes it as a potential antitumor agent.

<0.1 EU per 1 μg of the protein by the LAL method.