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Anti-Bcl-2-like protein 2 Bcl2L2 Antibody Picoband®

Anti-Bcl-2-like protein 2 Bcl2L2 Antibody Picoband®

ArtNr	BOS-PA1426-1
Hersteller	Boster
Menge	100 ug/vial
Kategorie	Oncology Food Safety Drugs Antibodies Flow Cytometry Immunohistochemistry Western Blot Immunocytochemistry Primary Antibodies By Organ Colorectal Cancer
Typ	Antibody Polyclonal
Format	Lyophilized
Applikationen	WB, FC, IHC, ICC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Sensitivity	>5000 cells
Citations	1. Gibson L, Holmgreen SP, Huang DC, Bernard O, Copeland NG, Jenkins NA, Sutherland GR, Baker E, Adams JM, Cory S (Oct 1996). "bcl-w, a novel member of the bcl-2 family, promotes cell survival". Oncogene 13 (4): 665–75. PMID 8761287. 2. "Entrez Gene: BCL2L2 BCL2-like 2".
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Bcl-2-like protein 2;Bcl2-L-2;Apoptosis regulator Bcl-W;BCL2L2;BCLW, KIAA0271;
Similar products	Apoptosis regulator Bcl-W
Lieferbar
Specificity	No cross reactivity with other proteins.
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	21 kDa
Calculated Molecular weight	20746 MW
Clonality	Polyclonal
Application Details	Immunohistochemistry (Paraffin-embedded Section), 0.5-1?g/ml, Human, Rat, Mouse, By Heat Western blot, 0.1-0.5?g/ml, Human, Rat, Mouse Immunohistochemistry (Frozen Section), 0.5-1?g/ml, Human Immunocytochemistry, 0.5-1?g/ml, Human Flow Cytometry (Fixed), 1-3?g/1x10⁶ cells, Human
Manufacturer - Gene Name	BCL2L2
Gene Full Name	Bcl-2-like protein 2
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Bcl-2-like protein 2 is a protein that in humans is encoded by the BCL2L2 gene. This gene encodes a pro-survival (anti-apoptotic) member of the bcl-2 protein family. Its gene is mapped to human chromosome 14q11.2-q12. In all, it has got 193 amino acids. Generally speaking, the BCL2 can be found in brain, colon and salivary gland. Acting as the anti- and pro-apoptotic regulators, it has played a vital role in reducing the cell apoptosis under cytotoxic conditions.
Immunogen	A synthetic peptide corresponding to a sequence in the middle region of human BCL2L2, identical to the related rat and mouse sequences.
Contents	Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category	Apoptosis, Cancer, Cell Biology, Intracellular, Oncoproteins, Oncoproteins/Suppressors
Protein Name	Bcl-2-like protein 2(Bcl2-L-2)
Protein Function	Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
Subcellular Localization	Mitochondrion membrane; Peripheral membrane protein. Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.
Description	Boster Bio Anti-Bcl-2-like protein 2 Bcl2L2 Antibody catalog # PA1426-1. Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines.
Sequence Similarities	Belongs to the Bcl-2 family.

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BOS-PA1426-1-datasheet.pdf

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