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Anti-P2X purinoceptor 7 P2RX7 Antibody Picoband® Europäischer Partner

ArtNr BOS-PA2129
Hersteller Boster
Menge 100 ug/vial
Kategorie
Typ Antibody Polyclonal
Format Lyophilized
Applikationen WB
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
Isotype IgG
Sensitivity <50pg/ml
Citations 1. Adriouch, S., Dox, C., Welge, V., Seman, M., Koch-Nolte, F., Haag, F. Cutting edge: a natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor. J. Immun. 169: 4108-4112, 2002.
2. Cabrini, G., Falzoni, S., Forchap, S. L., Pellegatti, P., Balboni, A., Agostini, P., Cuneo, A., Castoldi, G., Baricordi, O. R., Di Virgilio, F. A his-155 to tyr polymorphism confers gain-of-function to the human P2X7 receptor of human leukemic lymphocytes. J. Immun. 175: 82-89, 2005.
3. Lemaire, I., Falzoni, S., Leduc, N., Zhang, B., Pellegatti, P., Adinolfi, E., Chiozzi, P., Di Virgilio, F. Involvement of the purinergic P2X7 receptor in the formation of multinucleated giant cells. J. Immun. 177: 7257-7265, 2006.
4. Weber, F. C., Esser, P. R., Muller, T., Ganesan, J., Pellegatti, P., Simon, M. M., Zeiser, R., Idzko, M., Jakob, T., Martin, S. F. Lack of the purinergic receptor P2X (7) results in resistance to contact hypersensitivity. J. Exp. Med. 207: 2609-2619, 2010.
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias P2X purinoceptor 7;P2X7;ATP receptor;P2Z receptor;Purinergic receptor;P2rx7;
Similar products ligand gated ion channel, purinergic receptor P2X, ATP receptor antibody, Purinergic receptor antibody, P2X purinoceptor 7 antibody, P2X7 antibody, P2Z receptor antibody, 7 antibody
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Manufacturer - Category
Primary Antibodies
Manufacturer - Isotype
Rabbit IgG
Storage Conditions
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
39 kDa
Calculated Molecular weight
68392 MW
Clonality
Polyclonal
Application Details
Western blot, 0.1-0.5?g/ml, Human, Rat, Mouse
Manufacturer - Gene Name
P2RX7
Gene Full Name
P2X purinoceptor 7
Manufacturer - Specificity
No cross reactivity with other proteins.
Background
P2X purinoceptor 7, also called P2X7, is a protein that in humans is encoded by the P2RX7 gene. The product of this gene belongs to the family of purnoceptors for ATP. P2RX7 was mapped to chromosome 12q24 by fluorescence in situ hybridization. It is a receptor for ATP that acts as a ligand-gated ion channel. This gene is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. It could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of rat P2RX7, different from the related mouse sequence by one amino acid, and from the related human sequence by two amino acids.
Contents
Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.
Purification
Immunogen affinity purified.
Reconstitution
Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration
Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category
Ligand-Gated Ion Channels, Neuroscience, Neurotransmission, Receptors / Channels
Protein Name
P2X purinoceptor 7
Protein Function
Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.
Subcellular Localization
Cell membrane; Multi-pass membrane protein.
Description
Boster Bio Anti-P2X purinoceptor 7 P2RX7 Antibody catalog # PA2129. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug/vial
Lieferbar: In stock
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