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Anti-EAAT1/SLC1A3 Antibody Picoband® Europäischer Partner

ArtNr BOS-PA2185
Hersteller Boster
Menge 100 ug/vial
Kategorie
Typ Antibody Polyclonal
Format Lyophilized
Applikationen WB
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
Isotype IgG
Sensitivity >5000 cells
Citations 1. de Vries, B., Mamsa, H., Stam, A. H., Wan, J., Bakker, S. L. M., Vanmolkot, K. R. J., Haan, J., Terwindt, G. M., Boon, E. M. J., Howard, B. D., Frants, R. R., Baloh, R. W., Ferrari, M. D., Jen, J. C., van den Maagdenberg, A. M. J. M. Episodic ataxia associated with EAAT1 mutation C186S affecting glutamate reuptake. Arch. Neurol. 66: 97-101, 2009. Note: Errata: Arch. Neurol. 66: 497 only, 2009; Arch. Neurol. 66: 772 only, 2009.
2. Matsugami, T. R., Tanemura, K., Mieda, M., Nakatomi, R., Yamada, K., Kondo, T., Ogawa, M., Obata, K., Watanabe, M., Hashikawa, T., Tanaka, K. Indispensability of the glutamate transporters GLAST and GLT1 to brain development. Proc. Nat. Acad. Sci. 103: 12161-12166, 2006.
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Excitatory amino acid transporter 1;Sodium-dependent glutamate/aspartate transporter 1;GLAST-1;Solute carrier family 1 member 3;SLC1A3;EAAT1, GLAST, GLAST1;
Similar products high affinity, EA6 antibody, EAA1_HUMAN antibody, EAAT1 antibody, Excitatory amino acid transporter 1 antibody, FLJ25094 antibody, GLAST antibody, GLAST-1 antibody, GLAST1 antibody, Glial high affinity glutamate transporter antibody, glutamate/aspartate transporter, sodium-dependent antibody, High affinity neuronal glutamate transporter antibody, Slc1a3 antibody, Sodium dependent glutamate/aspartate transporter antibody, Sodium-dependent glutamate/aspartate transporter 1 antibody, Solute carrier family 1(glial high affinity glutamate transporter) member 3 antibody, Solute carrier family 1 member 3 antibody
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Manufacturer - Category
Primary Antibodies
Manufacturer - Isotype
Rabbit IgG
Storage Conditions
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
274 kDa
Calculated Molecular weight
59572 MW
Clonality
Polyclonal
Application Details
Immunohistochemistry (Paraffin-embedded Section), 0.5-1?g/ml, Rat, Human, By Heat

Immunohistochemistry (Frozen Section), 0.5-1?g/ml, Rat, Human
Western blot, 0.1-0.5?g/ml, Mouse, Rat, Human
Manufacturer - Gene Name
SLC1A3
Gene Full Name
Excitatory amino acid transporter 1
Manufacturer - Specificity
No cross reactivity with other proteins.
Background
Solute carrier family 1 (glial high-affinity glutamate transporter), member 3, also known as SLC1A3, EAAT1 or GLAST, is a protein that in humans is encoded by the SLC1A3 gene. This gene is a member of high affinity glutamate transporter family. SLC1A3 is mapped to chromosome 5p13.2 by fluorescence in situ hybridization (FISH). This gene transports L-glutamate and also L- and D-aspartate. It is essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. This gene acts as a symport by cotransporting sodium.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human EAAT1, different from the related rat and mouse sequences by three amino acids.
Contents
Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.
Purification
Immunogen affinity purified.
Reconstitution
Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration
Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category
Amino Acids, Cell Type Marker, Energy Metabolism, Metabolism, Neural Stem Cells, Neuroscience, Neurotransmitter, Signal Transduction, Stem Cells, Surface Molecules, Transporters
Protein Name
Excitatory amino acid transporter 1
Protein Function
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
Subcellular Localization
Membrane; Multi-pass membrane protein.
Description
Boster Bio Anti-EAAT1/SLC1A3 Antibody catalog # PA2185. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity
Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia.
Sequence Similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug/vial
Lieferbar: In stock
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