Anti-KCNC1 Antibody

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.

KCNC1

Potassium voltage-gated channel subfamily C member 1, also known as KV3.1, is a protein that in humans is encoded by the KCNC1 gene. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins, and it is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. This gene is mapped to 11p15.1. KCNC1 channels are prominently expressed in brain, and in retinal ganglion cells. High amounts of KCNC1 current decreased the timing accuracy of action potentials but enabled neurons to follow high-frequency stimuli. KCNC1 channels are important for the high-firing frequency of auditory and fast-spiking GABAergic interneurons, retinal ganglion cells; regulation of action potential duration in presynaptic terminals.

Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.

Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.

|neuroscience|neurotransmission|receptors / channels|potassium channels

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons.