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Anti-Caspase-6(P18)/CASP6 Antibody Picoband®

Anti-Caspase-6(P18)/CASP6 Antibody Picoband®

ArtNr	BOS-PA1441-1
Hersteller	Boster
Menge	100 ug/vial
Kategorie	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Cell Biology Cell Status Apoptosis Immunohistochemistry Western Blot Cardiovascular Research Ischemia & Reperfusion Injury Primary Antibodies By Organ Colorectal Cancer Testicular & Prostate Cancer Gastric Cancer Uterine, Ovarian & Cervical Cancer
Typ	Antibody Polyclonal
Format	Lyophilized
Applikationen	WB, IHC
Specific against	Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Sensitivity	<50pg/ml
Citations	1. Fernandes-Alnemri, T., Litwack, G., Alnemri, E. S.Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.Cancer Res. 55: 2737-2742, 1995. 2. Nikolaev, A., McLaughlin, T., O'Leary, D. D. M., Tessier-Lavigne, M.APP binds DR6 to trigger axon pruning and neuron death via distinct caspases Nature 457: 981-989, 2009. 3. Orth, K., Chinnaiyan, A. M., Garg, M., Froelich, C. J., Dixit, V. M.The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A.J. Biol. Chem. 271: 16443-16446, 1996.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Caspase-6;CASP-6;3.4.22.59;Apoptotic protease Mch-2;Caspase-6 subunit p18;Caspase-6 subunit p11;Casp6;Mch2;
Similar products	Caspase 6, Apoptosis Related Cysteine Protease antibody, Apoptotic cysteine protease MCH2 antibody, Apoptotic protease MCH 2 antibody, Apoptotic protease Mch-2 antibody, Apoptotic protease MCH2 antibody, Casp 6 antibody, CASP-6 antibody, Casp6 antibody, Caspase 6 antibody, Caspase 6 apoptosis related cysteine protease antibody, Caspase 6 precursor antibody, apoptosis related cysteine peptidase antibody, Caspase-6 subunit p18 antibody, Caspase6 antibody, Human cysteine protease Mch2 isoform alpha antibody, Mch 2 antibody, Mch2 antibody, OTTHUMP00000162742 antibody, OTTHUMP00000162743 antibody
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Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	35 kDa
Calculated Molecular weight	31556 MW
Clonality	Polyclonal
Application Details	Immunohistochemistry (Paraffin-embedded Section), 0.5-1?g/ml, Mouse, Rat, By Heat Immunohistochemistry (Frozen Section), 0.5-1?g/ml, Rat, Mouse Western blot, 0.1-0.5?g/ml, Mouse, Rat
Manufacturer - Gene Name	CASP6
Gene Full Name	Caspase-6
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Caspase 6 is an enzyme that in humans is encoded by the caspase 6 gene. This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Using radiation hybrid mapping, the Caspase 6 gene is localized to human chromosome 4q25-q26. Caspase 6 functions as a downstream enzyme in the caspase activation cascade. And Caspase 6 can cleave lamin A to its signature apoptotic fragment.
Immunogen	A synthetic peptide corresponding to a sequence at the N-terminus of rat Caspase-6(P18), different from the related mouse sequence by two amino acids.
Contents	Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category	Alzheimer's Disease, Apoptosis, Apoptotic Markers, Cancer, Caspases, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Metabolism, Metabolism Processes, Neurodegenerative Disease, Neurology Process, Neuroscience, Pathways and Processes
Protein Name	Caspase-6
Protein Function	Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly (ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death (By similarity).
Subcellular Localization	Cytoplasm.
Description	Boster Bio Anti-Caspase-6 (P18)/CASP6 Antibody catalog # PA1441-1. Tested in IHC, WB applications. This antibody reacts with Mouse, Rat.

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BOS-PA1441-1-datasheet.pdf

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