Anti-Podoplanin/gp36/PDPN Antibody Picoband®

ArtNr	BOS-PA1675
Hersteller	Boster
Menge	100 ug/vial
Kategorie	Oncology Food Safety Vitamines Neuroscience Neuroinflammation Neural Signaling Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Western Blot Primary Antibodies By Organ Lung Cancer
Typ	Antibody Polyclonal
Format	Lyophilized
Applikationen	WB
Specific against	Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Sensitivity	<10pg/ml
Citations	1. Kato, Y., Fujita, N., Kunita, A., Sato, S., Kaneko, M., Osawa, M., Tsuruo, T. Molecular identification of Aggrus/T1-alpha as a platelet aggregation-inducing factor expressed in colorectal tumors. J. Biol. Chem. 278: 51599-51605, 2003. 2. Ma, T., Yang, B., Matthay, M. A., Verkman, A. S. Evidence against a role of mouse, rat, and two cloned human T1-alpha isoforms as a water channel or a regulator of aquaporin-type water channels. Am. J. Resp. Cell Molec. Biol. 19: 143-149, 1998. 3. Schacht, V., Ramirez, M. I., Hong, Y.-K., Hirakawa, S., Feng, D., Harvey, N., Williams, M., Dvorak, A. M., Dvorak, H. F., Oliver, G., Detmar, M. T1-alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBO J. 22: 3546-3556, 2003.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Podoplanin;E11 antigen epitope;Glycoprotein 38;Gp38;OTS-8;RTI140;T1-alpha;T1A;Type I cell 40 kDa protein;Pdpn;Gp38, Ots8;
Similar products	AGGRUS antibody, GLYCOPROTEIN 36 KD antibody, Glycoprotein 36 antibody, gp 36 antibody, GP 38 antibody, GP 40 antibody, gp36 antibody, GP38 antibody, GP40 antibody, HT1A 1 antibody, HT1A1 antibody, hT1alpha1 antibody, hT1alpha2 antibody, Lung type I cell membrane associated glycoprotein antibody, Lung type I cell membrane associated glycoprotein isoform a antibody, Lung type I cell membrane associated glycoprotein T1A 2 antibody, OTS 8 antibody, OTS8 antibody, OTTHUMP00000009640 antibody, OTTHUMP00000044504 antibody, PA2.26 antibody, PA2.26 antigen antibody, PDPN antibody, PDPN_HUMAN antibody, Podoplanin antibody, PSEC0003 antibody, PSEC0025 antibody, T1 alpha antibody, T1 ALPHA GENE antibody, T1-alpha antibody, T1A 2 antibody, T1A antibody, TIA 2 antibody, TIA2 antibody
Lieferbar
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	38 kDa
Calculated Molecular weight	17579 MW
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5?g/ml, Mouse, Rat
Manufacturer - Gene Name	PDPN
Gene Full Name	Podoplanin
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	PDPN (Podoplanin), also called T1A, T1A2, GP36, OTS8 or AGGRUS, is a protein that in humans is encoded by the PDPN gene. This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The PDPN gene is mapped to chromosome 1 by the International radiation Hybrid mapping consortium. The physiological function of PDPN may be related to its mucin-type character. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Immunohistochemical analysis of PDPN in placenta, kidney, lung, and nasal polyps showed expression at the apical plasma membrane of vascular endothelial cells and in alveolar epithelial cells. Overexpression of rat PDPN in human and rodent endothelial cells promoted formation of elongated cell extensions and significantly increased endothelial cell adhesion, migration, and tube formation. Inhibition of PDPN expression by small interfering RNAs decreased cell adhesion in cultured human dermal lymphatic endothelial cells.
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminus of rat Podoplanin/gp36, different from the related mouse sequence by one amino acid.
Contents	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2mg Na2HPO4, 0.05 mg NaN3.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category	Vasculature
Protein Name	Podoplanin
Protein Function	May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels (By similarity).
Subcellular Localization	Membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles.
Description	Boster Bio Anti-Podoplanin/gp36/PDPN Antibody catalog # PA1675. Tested in WB applications. This antibody reacts with Mouse, Rat.
Tissue Specificity	In adult kidney, expressed on the urinary surface and foot processes of podocytes and in parietal epithelial cells of Bowman's capsule where it is localized to luminal surfaces. In lung, expressed exclusively on luminal surfaces of type I alveolar epithelial cells and pleural mesothelial cells. Not expressed in type II alveolar cells. In bone, expressed in osteocytes and osteoblasts. In spleen, liver, stomach and intestine, expressed in mesoepithelium. Also expressed in thymic epithelial cells, choroid plexus and leptomeninges.
Sequence Similarities	Belongs to the heparin-binding growth factors family.

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