Anti-MMP1 Antibody Picoband®

Rabbit IgG

54 kDa

Western blot, 0.1-0.25?g/ml

Immunohistochemistry (Paraffin-embedded Section), 0.5-1?g/ml

Immunocytochemistry/Immunofluorescence, 2?g/ml

Flow Cytometry (Fixed), 1-3?g/1x10⁶ cells

ELISA, 0.1-0.5?g/ml

matrix metallopeptidase 1

Matrix metalloproteinase-1 (MMP-1), also known as interstitial collagenase and fibroblast collagenase, is an enzyme that in humans is encoded by the MMP1 gene. MMP-1 was the first vertebrate collagenase both purified to homogeneity as a protein, and cloned as a cDNA. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. It is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.

Each vial contains 4 mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg NaN3.

Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.

Chromosome Structure, DNA/RNA, DNA Damage & Repair, Epigenetics and Nuclear Signaling

Extracellular matrix.