Hersteller |
Boster
|
Kategorie |
|
Typ |
Antibody |
Specific against |
Human |
Format |
Liquid |
Applikationen |
WB |
Menge |
100ul |
Host |
Rabbit |
ArtNr |
BOS-A00947 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Manufacturers Product Category |
Primary Antibodies |
Manufacturers Research Category |
Drug Metabolism, Lipases, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathways, Metabolism, Mitochondrial Metabolism, Pathways and Processes, Signal Transduction |
Short Description |
Boster Bio Anti-CYP2A6V2 Antibody (Catalog # A00947). Tested in WB applications. This antibody reacts with Human. |
Description |
Boster Bio Anti-CYP2A6V2 Antibody (Catalog # A00947). Tested in WB applications. This antibody reacts with Human. |
Background |
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Fernandez-Salguero P., Am. J. Hum. Genet. 57:651-660(1995). |
Gene Name |
CYP2A6 |
Clonality |
Polyclonal |
Concentration |
1 mg/ml |
Contents |
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Application Details |
Western blotting: 1:500~1:3000 |
Immunogen |
Synthesized peptide derived from N-terminal of human CYP2A6V2. |
Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Storage |
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
Gene Full Name |
Cytochrome P450 2A6 |
Molecular Weight |
56501 MW |
Protein Function |
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1, 4- cineole 2-exo-monooxygenase. Possesses low phenacetin O- deethylation activity.. |
Subcellular Localization |
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
Tissue Specificity |
Liver.. |
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