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Anti-TMEPA PMEPA1 Antibody

Anti-TMEPA PMEPA1 Antibody

ArtNr	BOS-A05994
Hersteller	Boster
Menge	100 ul
Kategorie	Neuroscience Neural Lineage Markers Targets for Rodent Neurosciences Antibodies Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies Neurodegeneration Markers
Typ	Antibody
Format	Liquid
Applikationen	WB, IF, IHC
Specific against	Human (Homo sapiens)
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Protein TMEPAI;Prostate transmembrane protein androgen induced 1;Solid tumor-associated 1 protein;Transmembrane prostate androgen-induced protein;PMEPA1;STAG1, TMEPAI;
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	31609 MW
Clonality	Polyclonal
Application Details	Western blotting: 1:500~1:3000 Immunohistochemistry: 1:50~1:100 Immunofluorescence: 1:100~1:500
Manufacturer - Gene Name	PMEPA1
Gene Full Name	Protein TMEPAI
Background	Involved in down-regulation of the androgen receptor (AR). Enhances ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4. Xu L.L., Genomics 66:257-263(2000). Rae F.K., Mol. Carcinog. 32:44-53(2001). Deloukas P., Nature 414:865-871(2001).
Immunogen	Synthesized peptide derived from internal of human TMEPA.
Contents	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration	1 mg/ml
Protein Function	Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514).
Subcellular Localization	Early endosome membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
Short Description	Boster Bio Anti-TMEPA PMEPA1 Antibody (Catalog # A05994). Tested in WB, IHC, IF applications. This antibody reacts with Human.
Description	Boster Bio Anti-TMEPA PMEPA1 Antibody (Catalog # A05994). Tested in WB, IHC, IF applications. This antibody reacts with Human.
Tissue Specificity	Highest expression in prostate. Also expressed in ovary.

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BOS-A05994-datasheet.pdf

BOS-A05994-safety-datasheet.pdf