« Back
Home /
Anti-TMEPA PMEPA1 Antibody

Anti-TMEPA PMEPA1 Antibody

Manufacturer	Boster
Category	Neuroscience Neural Lineage Markers Antibodies Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies Neurodegeneration Markers;Research Area Targets for Rodent Neurosciences
Type	Antibody
Specific against	Human
Format	Liquid
Applications	WB, IF, IHC
Amount	100ul
Host	Rabbit
Item no.	BOS-A05994
eClass 6.1	32160702
eClass 9.0	32160702
Available
Manufacturers Product Category	Primary Antibodies
Short Description	Boster Bio Anti-TMEPA PMEPA1 Antibody (Catalog # A05994). Tested in WB, IHC, IF applications. This antibody reacts with Human.
Description	Boster Bio Anti-TMEPA PMEPA1 Antibody (Catalog # A05994). Tested in WB, IHC, IF applications. This antibody reacts with Human.
Background	Involved in down-regulation of the androgen receptor (AR). Enhances ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4. Xu L.L., Genomics 66:257-263(2000). Rae F.K., Mol. Carcinog. 32:44-53(2001). Deloukas P., Nature 414:865-871(2001).
Gene Name	PMEPA1
Clonality	Polyclonal
Concentration	1 mg/ml
Contents	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Application Details	Western blotting: 1:500~1:3000 Immunohistochemistry: 1:50~1:100 Immunofluorescence: 1:100~1:500
Immunogen	Synthesized peptide derived from internal of human TMEPA.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Gene Full Name	Protein TMEPAI
Molecular Weight	31609 MW
Protein Function	Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514)..
Subcellular Localization	Early endosome membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
Tissue Specificity	Highest expression in prostate. Also expressed in ovary.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 100ul

available

Delivery expected until 7/5/2024