|
Hersteller |
Boster
|
|
Kategorie |
|
|
Typ |
Antibody |
|
Specific against |
other |
|
Applikationen |
WB |
|
Menge |
100ug/vial |
|
Host |
Rabbit |
|
ArtNr |
BOS-A19835 |
|
eClass 6.1 |
32160702 |
|
eClass 9.0 |
32160702 |
|
Lieferbar |
 |
| Gene name |
DROSHA |
| Clonality |
Polyclonal |
| Conjugate |
No |
| Contents |
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Description |
Polyclonal antibody for DROSHA detection. Host: Rabbit.Size: 100ug/vial. Tested applications: WB. Reactive species: Human. DROSHA information: Molecular Weight: 159316 MW; Subcellular Localization: Nucleus . Nucleus, nucleolus . A fraction is translocated to the nucleolus during the S phase of the cell cycle. Localized in GW bodies (GWBs), also known as P-bodies; Tissue Specificity: Ubiquitous. |
| Uniprot ID |
Q9NRR4 |
| Immunogen |
A peptide derived from human RNase III Drosha. Immunogen sequence location: 774 - 823 |
| Purification |
The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen. |
| Storage |
At -20° C for one year. After reconstitution, at 4° C for one month. It can also be aliquotted and stored frozen at -20° C for a longer time.Avoid repeated freezing and thawing. |
| Application details |
User need to optimize the dilution ratio for this antibody |
| Reactivity |
Human, Mouse |
| Research category |
|epigenetics and nuclear signaling|dna / rna|rna processing|rnai|
epigenetics and nuclear signaling|dicer|chip'ing antibodies|nuclear signaling pathways|nuclear receptors|nuclear pore complex |
| Synonyms |
Ribonuclease 3, 3.1.26.3 , Protein Drosha , Ribonuclease III, RNase III, p241, DROSHA, RN3, RNASE3L, RNASEN, |
| Molecular weight |
159316 MW |
| Protein function |
Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA- ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double- strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. . |
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