Anti-RNase III Drosha Antibody

Hersteller Boster
Kategorie
Typ Antibody
Specific against other
Applikationen WB
Menge 100ug/vial
Host Rabbit
ArtNr BOS-A19835
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Gene name
DROSHA
Clonality
Polyclonal
Conjugate
No
Contents
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Description
Polyclonal antibody for DROSHA detection. Host: Rabbit.Size: 100ug/vial. Tested applications: WB. Reactive species: Human. DROSHA information: Molecular Weight: 159316 MW; Subcellular Localization: Nucleus . Nucleus, nucleolus . A fraction is translocated to the nucleolus during the S phase of the cell cycle. Localized in GW bodies (GWBs), also known as P-bodies; Tissue Specificity: Ubiquitous.
Uniprot ID
Q9NRR4
Immunogen
A peptide derived from human RNase III Drosha. Immunogen sequence location: 774 - 823
Purification
The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
Storage
At -20° C for one year. After reconstitution, at 4° C for one month. It can also be aliquotted and stored frozen at -20° C for a longer time.Avoid repeated freezing and thawing.
Application details
User need to optimize the dilution ratio for this antibody
Reactivity
Human, Mouse
Research category
|epigenetics and nuclear signaling|dna / rna|rna processing|rnai| epigenetics and nuclear signaling|dicer|chip'ing antibodies|nuclear signaling pathways|nuclear receptors|nuclear pore complex
Synonyms
Ribonuclease 3, 3.1.26.3 , Protein Drosha , Ribonuclease III, RNase III, p241, DROSHA, RN3, RNASE3L, RNASEN,
Molecular weight
159316 MW
Protein function
Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA- ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double- strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. .

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Menge: 100ug/vial
Lieferbar: In stock
Listenpreis: 386,89 €
Preis: 386,89 €
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