Anti-RNase III Drosha Antibody

Primary Antibodies

Boster Bio Anti-RNase III Drosha Antibody (Catalog# A19835). Tested in WB, IHC-P, IF (paraffin), ELISA applications. This antibody reacts with Human, Mouse.

DROSHA

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Western Blot, 1:500 - 1:2000
IHC-P, 1:100-1:300
ELISA, 1:10000
Not yet tested in other applications.

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

Ribonuclease 3

Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA- ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double- strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.

Ubiquitous.