ArtNr |
BOS-A19835 |
Hersteller |
Boster
|
Menge |
100 ul |
Kategorie |
|
Typ |
Antibody |
Format |
Liquid |
Applikationen |
WB, IF, ELISA, IHC-P |
Specific against |
Human (Homo sapiens), Mouse (Murine, Mus musculus) |
Host |
Rabbit |
Isotype |
IgG |
Sensitivity |
>5000 cells |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
DROSHA;RN3;RNASE3L;RNASEN;Ribonuclease 3;Protein Drosha;Ribonuclease III;RNase III;p241 |
Lieferbar |
|
Manufacturer - Category |
Primary Antibodies |
Manufacturer - Isotype |
Rabbit IgG |
Storage Conditions |
Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
Observed Molecular Weight |
159316 MW |
Clonality |
Polyclonal |
Application Details |
Western Blot, 1:500 - 1:2000 IHC-P, 1:100-1:300 ELISA, 1:10000 Not yet tested in other applications. |
Manufacturer - Gene Name |
DROSHA |
Gene Full Name |
Ribonuclease 3 |
Immunogen |
A peptide derived from human RNase III Drosha. Immunogen sequence location: 774 - 823 |
Contents |
PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification |
The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen. |
Concentration |
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure. |
Manufacturer - Research Category |
2339, DNA/RNA, Epigenetics and Nuclear Signaling, Nuclear Receptors, Nuclear Signaling Pathways, RNA Processing |
Protein Function |
Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA- ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double- strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. |
Subcellular Localization |
Nucleus. Nucleus, nucleolus. A fraction is translocated to the nucleolus during the S phase of the cell cycle. Localized in GW bodies (GWBs), also known as P-bodies. |
Short Description |
Boster Bio Anti-RNase III Drosha Antibody (Catalog# A19835). Tested in WB, IHC-P, IF (paraffin), ELISA applications. This antibody reacts with Human, Mouse. |
Description |
Boster Bio Anti-RNase III Drosha Antibody (Catalog# A19835). Tested in WB, IHC-P, IF (paraffin), ELISA applications. This antibody reacts with Human, Mouse. |
Tissue Specificity |
Ubiquitous. |
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