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Anti-Jarid1c Antibody ChIP Grade

Anti-Jarid1c Antibody ChIP Grade

ArtNr	BOS-CI1111
Hersteller	Boster
Menge	100 ul
Kategorie	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Molecular Targets for Neuroscience Neural Signaling Antibodies Western Blot Primary Antibodies By Organ Breast Cancer
Typ	Antibody
Applikationen	WB
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Lysine-specific demethylase 5C,1.14.11.-,Histone demethylase JARID1C,Jumonji/ARID domain-containing protein 1C,Protein SmcX,Protein Xe169,KDM5C,DXS1272E, JARID1C, SMCX, XE169,
Lieferbar
Storage Conditions	At -20°C for one year, at 4°C for one month. Avoid repeated freezing and thawing.
Observed Molecular Weight	175720 MW
Clonality	Polyclonal
Manufacturer - Gene Name	KDM5C
Background	Jarid1c is a histone demethylase which specifically demethylates lysine 4 of histone H3, thereby playing a central role in the regulation of transcription and chromatin remodelling. Jarid1c demethylates the trimethylated and dimethylated lysine 4, but not the monomethylated form. Further, Jarid1c participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Mutations in the Jarid1c gene have been associated with X-linked mental retardation.
Immunogen	This antibody is raised in rabbit against mouse Jarid1c (jumonji, AT rich interactive domain 1C), using 3 KLH-conjugated synthetic peptides containing sequences from the inner part of the protein.
Contents	Whole antiserum from rabbit containing 0.05% azide.
Purification	Whole antiserum
Manufacturer - Research Category	\|epigenetics and nuclear signaling\|nuclear signaling pathways\|nuclear receptors\|co-activators/co-repressors\| epigenetics and nuclear signaling\|transcription\|other factors\|co-factors\|chromatin modifying enzymes\|jumonji containing proteins\|chip'ing antibodies
Protein Function	Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).

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BOS-CI1111-datasheet.pdf

BOS-CI1111-safety-datasheet.pdf