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Anti-Jarid1c Antibody ChIP Grade

Anti-Jarid1c Antibody ChIP Grade

Item no.	BOS-CI1111
Manufacturer	Boster
Amount	100 ul
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Molecular Targets for Neuroscience Neural Signaling Antibodies Western Blot Primary Antibodies By Organ Breast Cancer
Type	Antibody
Applications	WB
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Lysine-specific demethylase 5C,1.14.11.-,Histone demethylase JARID1C,Jumonji/ARID domain-containing protein 1C,Protein SmcX,Protein Xe169,KDM5C,DXS1272E, JARID1C, SMCX, XE169,
Available
Storage Conditions	At -20°C for one year, at 4°C for one month. Avoid repeated freezing and thawing.
Observed Molecular Weight	175720 MW
Clonality	Polyclonal
Manufacturer - Gene Name	KDM5C
Background	Jarid1c is a histone demethylase which specifically demethylates lysine 4 of histone H3, thereby playing a central role in the regulation of transcription and chromatin remodelling. Jarid1c demethylates the trimethylated and dimethylated lysine 4, but not the monomethylated form. Further, Jarid1c participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Mutations in the Jarid1c gene have been associated with X-linked mental retardation.
Immunogen	This antibody is raised in rabbit against mouse Jarid1c (jumonji, AT rich interactive domain 1C), using 3 KLH-conjugated synthetic peptides containing sequences from the inner part of the protein.
Contents	Whole antiserum from rabbit containing 0.05% azide.
Purification	Whole antiserum
Manufacturer - Research Category	\|epigenetics and nuclear signaling\|nuclear signaling pathways\|nuclear receptors\|co-activators/co-repressors\| epigenetics and nuclear signaling\|transcription\|other factors\|co-factors\|chromatin modifying enzymes\|jumonji containing proteins\|chip'ing antibodies
Protein Function	Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-CI1111-datasheet.pdf

BOS-CI1111-safety-datasheet.pdf