Anti-Human CD44 Monoclonal Antibody FITC Conjugated, Flow Validated

Store at 2-8°C. Avoid repeated freeze-thaw cycles.

Liquid, in PBS, pH7.2, <0.09% NaN3 and 0.2% (w/v) BSA

User needs to optimize the dilution ratio for this antibody.

CD44 antigen

PBS pH 7.2, 0.2% (w/v) BSA, 0.09% (w/v) sodium azide

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity).

Boster Bio Anti-Human CD44 Monoclonal Antibody FITC Conjugated, Flow Validated (Catalog# FC00052-FITC). Tested in Flow Cytometry application(s). This antibody reacts with Human.

Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.