Hersteller |
Boster
|
Kategorie |
|
Typ |
Antibody Monoclonal |
Specific against |
Human |
Clon |
AAHB-16 |
Isotype |
IgG |
Format |
Liquid |
Applikationen |
WB, IHC |
Menge |
100 ul |
Host |
Rabbit |
ArtNr |
BOS-M01124-2 |
Targets |
PDPN |
eClass 6.1 |
32160702 |
eClass 9.0 |
42030590 |
Lieferbar |
|
Manufacturers Product Category |
Primary Antibodies, Rabbit Monoclonal Antibodies |
Manufacturers Research Category |
Angiogenesis, Cardiovascular, Cell Type Markers, Tags & Cell Markers, Vasculature |
Short Description |
Boster Bio Anti-Podoplanin PDPN Rabbit Monoclonal Antibody catalog # M01124-2. Tested in WB, IHC applications. This antibody reacts with Human. |
Description |
Boster Bio Anti-Podoplanin PDPN Rabbit Monoclonal Antibody catalog # M01124-2. Tested in WB, IHC applications. This antibody reacts with Human. |
Gene Name |
PDPN |
Application Details |
WB 1:500-1:2000 IHC 1:50-1:200 |
Clonality |
Monoclonal |
Concentration |
Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure. |
Contents |
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
Immunogen |
A synthesized peptide derived from human Podoplanin |
Purification |
Affinity-chromatography |
Storage |
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
Gene Full Name |
Podoplanin |
Molecular Weight |
16698 MW |
Protein Function |
May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.. |
Subcellular Localization |
Membrane ; Single-pass type I membrane protein. Cell projection, filopodium membrane ; Single-pass type I membrane protein. Cell projection, lamellipodium membrane ; Single-pass type I membrane protein. Cell projection, microvillus membrane ; Single-pass type I membrane protein. Cell projection, ruffle membrane ; Single-pass type I membrane protein. Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles.. |
Tissue Specificity |
Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.. |
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