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Anti-Cubilin CUBN Rabbit Monoclonal Antibody

Hersteller Boster
Kategorie
Typ Antibody Monoclonal
Specific against Human
Clon GA-3
Isotype IgG
Format Liquid
Applikationen WB, IHC
Menge 100 ul
Host Rabbit
ArtNr BOS-M03670
eClass 6.1 32160702
eClass 9.0 42030590
Lieferbar
Manufacturers Product Category
Primary Antibodies, Rabbit Monoclonal Antibodies
Manufacturers Research Category
Cancer, Cancer Metabolism, Cofactors, Vitamins/Minerals, Endocrine Metabolism, Hormone Biosynthesis, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism of Lipids and Lipoproteins, Pathways and Processes, Signal Transduction, Vitamins/Minerals
Short Description
Boster Bio Anti-Cubilin CUBN Rabbit Monoclonal Antibody catalog # M03670. Tested in WB, IHC applications. This antibody reacts with Human.
Description
Boster Bio Anti-Cubilin CUBN Rabbit Monoclonal Antibody catalog # M03670. Tested in WB, IHC applications. This antibody reacts with Human.
Gene Name
CUBN
Application Details
WB 1:500-1:2000
IHC 1:50-1:200
Clonality
Monoclonal
Concentration
Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Contents
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Immunogen
A synthesized peptide derived from human Cubilin
Purification
Affinity-chromatography
Storage
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Gene Full Name
Cubilin
Molecular Weight
398736 MW
Protein Function
Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface..
Subcellular Localization
Apical cell membrane ; Peripheral membrane protein. Cell membrane ; Peripheral membrane protein. Membrane, coated pit. Endosome. Lysosome membrane ; Peripheral membrane protein. Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells..
Tissue Specificity
Expressed in kidney proximal tubule cells, placenta, visceral yolk-sac cells and in absorptive intestinal cells. Expressed in the epithelium of intestine and kidney.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ul
Lieferbar: In stock
lieferbar

Lieferung vsl. bis 02.05.2024 

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