Hersteller |
Boster
|
Kategorie |
|
Typ |
Antibody Monoclonal |
Specific against |
Human |
Clon |
GA-3 |
Isotype |
IgG |
Format |
Liquid |
Applikationen |
WB, IHC |
Menge |
100 ul |
Host |
Rabbit |
ArtNr |
BOS-M03670 |
eClass 6.1 |
32160702 |
eClass 9.0 |
42030590 |
Lieferbar |
|
Manufacturers Product Category |
Primary Antibodies, Rabbit Monoclonal Antibodies |
Manufacturers Research Category |
Cancer, Cancer Metabolism, Cofactors, Vitamins/Minerals, Endocrine Metabolism, Hormone Biosynthesis, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism of Lipids and Lipoproteins, Pathways and Processes, Signal Transduction, Vitamins/Minerals |
Short Description |
Boster Bio Anti-Cubilin CUBN Rabbit Monoclonal Antibody catalog # M03670. Tested in WB, IHC applications. This antibody reacts with Human. |
Description |
Boster Bio Anti-Cubilin CUBN Rabbit Monoclonal Antibody catalog # M03670. Tested in WB, IHC applications. This antibody reacts with Human. |
Gene Name |
CUBN |
Application Details |
WB 1:500-1:2000 IHC 1:50-1:200 |
Clonality |
Monoclonal |
Concentration |
Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure. |
Contents |
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
Immunogen |
A synthesized peptide derived from human Cubilin |
Purification |
Affinity-chromatography |
Storage |
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
Gene Full Name |
Cubilin |
Molecular Weight |
398736 MW |
Protein Function |
Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.. |
Subcellular Localization |
Apical cell membrane ; Peripheral membrane protein. Cell membrane ; Peripheral membrane protein. Membrane, coated pit. Endosome. Lysosome membrane ; Peripheral membrane protein. Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells.. |
Tissue Specificity |
Expressed in kidney proximal tubule cells, placenta, visceral yolk-sac cells and in absorptive intestinal cells. Expressed in the epithelium of intestine and kidney. |
Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.
Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.