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Anti-Cubilin CUBN Rabbit Monoclonal Antibody

Anti-Cubilin CUBN Rabbit Monoclonal Antibody

Manufacturer	Boster
Category	Food Safety Vitamines Neuroscience Neuroinflammation Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Aging & Neurological Disorders Antibodies Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Monoclonal
Specific against	Human
Clone	GA-3
Isotype	IgG
Format	Liquid
Applications	WB, IHC
Amount	100 ul
Host	Rabbit
Item no.	BOS-M03670
eClass 6.1	32160702
eClass 9.0	42030590
Available
Manufacturers Product Category	Primary Antibodies, Rabbit Monoclonal Antibodies
Manufacturers Research Category	Cancer, Cancer Metabolism, Cofactors, Vitamins/Minerals, Endocrine Metabolism, Hormone Biosynthesis, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism of Lipids and Lipoproteins, Pathways and Processes, Signal Transduction, Vitamins/Minerals
Short Description	Boster Bio Anti-Cubilin CUBN Rabbit Monoclonal Antibody catalog # M03670. Tested in WB, IHC applications. This antibody reacts with Human.
Description	Boster Bio Anti-Cubilin CUBN Rabbit Monoclonal Antibody catalog # M03670. Tested in WB, IHC applications. This antibody reacts with Human.
Gene Name	CUBN
Application Details	WB 1:500-1:2000 IHC 1:50-1:200
Clonality	Monoclonal
Concentration	Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Contents	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Immunogen	A synthesized peptide derived from human Cubilin
Purification	Affinity-chromatography
Storage	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Gene Full Name	Cubilin
Molecular Weight	398736 MW
Protein Function	Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface..
Subcellular Localization	Apical cell membrane ; Peripheral membrane protein. Cell membrane ; Peripheral membrane protein. Membrane, coated pit. Endosome. Lysosome membrane ; Peripheral membrane protein. Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells..
Tissue Specificity	Expressed in kidney proximal tubule cells, placenta, visceral yolk-sac cells and in absorptive intestinal cells. Expressed in the epithelium of intestine and kidney.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

available

Delivery expected until 5/30/2024